BUF @ CLE prediction: AI-powered NFL analysis
NFL · Week 16 · FirstEnergy Stadium
VS
21/12/2025
Kickoff 19:00 (Paris time)
Kickoff 19:00 (Paris time)
Analysis published before kickoff
Best odds across books (CLV)
Transparent method
Spread
BUF
-10.5
BUF
Spread
CLE
+10.5
CLE
Total (O/U)
41.5
points
nflverse reference lines
Our picks for this match
Official
CLE +10.5
Edge vs market
—
Odds
1.91
Market
Spread
Pick taken on 20/12 à 01:00 — odds at the time: 1.91 (CLV tracking)
INJURIES & ABSENCES
Buffalo BillsAr'maj Reed-Adams
Ed Oliver
Jalon Kilgore
Jude Bowry
Skyler Bell
T.J. Sanders
Cleveland BrownsDillon Gabriel
Dylan Sampson
Jeremiah Owusu-Koramoah
Kendrick Green
Teven Jenkins
Tyson Campbell
Official injury report — ESPN feed, updated daily.
Key Factors
Points scored/g
32.6vs16.0
Points allowed/g
25.4vs24.2
Pass EPA
6.14vs-9.49
Turnover diff.
0.0vs-1.0
Record
12-5vs5-12
Roof: outdoors
Surface: grass
FirstEnergy Stadium — Cleveland, OH
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Head-to-head
2BUF
CLE1
20/11/22CLE — BUF23 – 31
10/11/19BUF — CLE16 – 19
18/12/16CLE — BUF13 – 33
Form & statistics
Team Comparison
8 of 65 model features (last 5-10 games)
BUF
STAT
CLE
32.6
16.0
25.4
24.2
397
287
227
203
169
84
0.0
-1.0
+12.4
-15.4
50.0%
27.7%
Frequently asked questions
When was BUF @ CLE played?
This NFL game was played on 2025-12-21.
Where can I find the prediction for BUF @ CLE?
This ProbWin page shows the predictions our model published before the game (spreads and totals), the key stats for both sides, and the settled result — every prediction is kept, win or lose, in our public track record.
How are these predictions calculated?
Our NFL statistical models are trained on league history and recomputed daily from team and player stats plus market odds. Every prediction is published before the game and its result is settled publicly.
